SHP-2 (PTPN11) is a ubiquitously expressed, nonreceptor protein tyrosine phosphatase (PTP). It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens, and extracellular matrices in the control of cell growth, differentiation, migration, and death (1).
What is SHP-2 antibody and how is it made?
* Avoid repeated exposure to skin. SHP-2 Antibody detects endogenous levels of total SHP-2 independent of phosphorylation. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the amino-terminal domain of human SHP-2.
What is the targetshp-2 antibody?
SHP-2 Antibody detects endogenous levels of total SHP-2 independent of phosphorylation.
Is shp2-pd-1 interaction a novel opportunity for small molecular PD-1 inhibitors?
Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors Small molecular PD-1 inhibitors are lacking in current immuno-oncology clinic.
